Spindle Cell Dilemma: A Rare Autopsy Case of Sarcomatoid Mesothelioma Presenting with Pleural and Peritoneal Plaques

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Authors

• Casey P. Schukow, Corewell Health East Resident
• Jessica D. Anderson, Corewell Health East
• John D. Schwartz, Corewell Health East

Description

• Sarcomatoid (or spindle cell) mesothelioma is a rare and aggressive variant, accounting for 10- 20% of diagnoses (Klebe et al, 2010) 
• It has a poor prognosis, with an average survival of five to twelve months, and is predominately caused by asbestos exposure
• Pleural disease is more common (98%) than peritoneal (2%), with fewer than fifty cases of the latter reported 
•  The spindle cells in these tumors can appear cytologically bland and may not express mesothelial markers, leading to diagnostic challenges

Publication Date

4-15-2025

Keywords

spindle cell, mesothelioma

Disciplines

Pathology

Recommended Citation

Schukow CP, Anderson JD, Schwartz JD.Spindle Cell Dilemma: A Rare Autopsy Case of Sarcomatoid Mesothelioma Presenting with Pleural and Peritoneal Plaques. Presented at: Corewell Health East Resident/Fellow Research Day; 2025 April 16, Virtual

Comments

Corewell Health East Resident/Fellow Research Day; 2025 April 16, Virtual