Advancing proton therapy: Dosimetric superiority of proton arc therapy over IMPT in esophageal cancer treatment.

Authors

• Xiaoda Cong, Corewell Health East
• Ebin Sebastian, Corewell Health East Resident
• Peilin Liu, Corewell Health East
• Xiaoqiang Li, Corewell Health East
• James Dolan, Corewell Health East
• Rohan L. Deraniyagala, Corewell Health East
• Craig W. Stevens, Corewell Health East
• Peter Y. Chen, Corewell Health East
• Xuanfeng Ding, Corewell Health East

Document Type

Article

Publication Date

5-2026

Publication Title

Journal of applied clinical medical physics [electronic resource] / American College of Medical Physics

Abstract

BACKGROUND AND AIMS: Esophageal cancer presents significant treatment challenges due to its proximity to critical structures such as the heart, lungs, and spinal cord. While intensity-modulated proton therapy (IMPT) improves dose conformity, it is limited by factors such as the number of beam angles and lateral penumbra. Proton arc therapy (PAT) may overcome these issues by utilizing continuous gantry rotation to enhance conformity and spare organs-at-risk (OARs). This study compared PAT and IMPT in esophageal cancer, focusing on dosimetric outcomes, and dose-averaged linear energy transfer (LET

METHODS: A retrospective analysis was conducted on ten esophageal cancer patients with variable tumor characteristics. Treatment plans were created using Monaco v6.1 treatment planning system for both PAT and IMPT, maintaining identical robustness parameters (± 5 mm setup and ± 3.5% range uncertainties). Both modalities were prescribed a total dose of 50.4 Gy(RBE) in 28 fractions, ensuring ≥95% clinical target volume (CTV) coverage in the worst-case scenarios. Key metrics, including conformity index (CI), heterogeneity index (HI), and LET

RESULTS: PAT demonstrated superior dose conformity (CI: 0.67 ± 0.17 vs. 0.54 ± 0.13; p <  0.01) and reduced lung V20 (6.88% vs. 13.44%; p <  0.01) compared to IMPT. Critical structure sparing, including reduced spinal cord doses (max dose of (30.93 ± 10.85) Gy(RBE) vs (23.22 ± 9.55) Gy(RBE), p = 0.02), was achieved without compromising CTV coverage. PAT showed higher LET

CONCLUSIONS: PAT emerged as a promising modality for esophageal cancer treatment, delivering improved dose conformity and reduced OAR exposure. These advantages suggest PAT's potential to decrease radiation-associated complications and improve therapeutic outcomes, warranting further clinical validation.

Volume

27

Issue

5

First Page

e70607

Recommended Citation

Cong X, Sebastian E, Liu P, Li X, Dolan J, Dalfson R et al [Deraniyagala RL, Stevens CW, Chen PY, Ding X] Advancing proton therapy: dosimetric superiority of proton arc therapy over IMPT in esophageal cancer treatment. J Appl Clin Med Phys. 2026 May;27(5):e70607. doi: 10.1002/acm2.70607. PMID: 42086367

DOI

10.1002/acm2.70607

ISSN

1526-9914

PubMed ID

42086367