Profiles of Monoclonal Gammopathy With Renal Significance Versus Heavy-Burden Cases of Monoclonal Nephropathy

Document Type

Conference Proceeding

Publication Date

9-2018

Publication Title

Archives of Pathology and Laboratory Medicine

Abstract

Context: In cases of either myeloma or MCN, renal diseases affected by monoclonal immunoglobulin and/or light chains are usually severe, which is considered a ‘‘heavy burden’’ (HB), and such cases are overqualified for monoclonal gammopathy with renal significance (MGRS). The remaining types of monoclonal nephropathy with renal injury/significant proteinuria can be classified as MGRS. Our study goal was to retrospectively review a feasibility of MGRS concept in our monoclonal nephropathy cases. Design: Based on our current information, we evaluated our 2262 renal biopsies and identified 59 cases with monoclonal nephropathy, representing only 2.6% of all biopsies. We divided the monoclonal nephropathy cases into MGRS and HB groups for further analysis. Results: Among them, 31 of 59 cases (53%) were qualified as MGRS currently, including 13 AH/AL amyloidosis and other monoclonal nephropathies. The remaining 28 of 59 cases (47%) were classified into the HB group. The mean ages of patients in MGRS and HB groups were similar (.60 years old). The MGRS group had mean serum creatinine levels of 2.55 mg/dL, which was twice the reference range, but was significantly lower than that in the HB group (6.57 mg/dL). Conclusions: Our data indicate that the HB group had a significantly higher level of serum creatinine than the MGRS group had, supporting the view that HB renal disease may carry a worse prognosis.

Volume

142

Issue

9

First Page

e89

Comments

College of American Pathologists Annual Meeting, October 20-24,2018, Chicago, IL

Last Page

e89

DOI

10.5858/arpa.2018-0293-AB

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