Extranodal Noncutaneous Mature T-Cell Lymphoma: Common Laboratory Findings and Clinical Follow-Up

Document Type

Conference Proceeding

Publication Date

9-2018

Publication Title

Archives of Pathology and Laboratory Medicine

Abstract

Context: Mature T-cell lymphomas (TCLs) are relatively uncommon and may involve lymph nodes, skin, and extranodal noncutaneous organs. Nodal TCLs often present as late-stage disease with unfavorable outcomes. Extranodal noncutaneous TCLs, however, may remain as localized disease with different treatment strategy and improved prognosis.

Design: This study is focused on the common laboratory findings in patients with extranodal noncutaneous mature TCL with clinical follow-up and compared with nodal TCL.

Results: There were 9 patients, 5 men and 4 women (median age, 52 years; range, 33–96 years), including 1 extranodal T/NK–cell lymphoma; 1 ALCL, ALK type; 1 enteropathy associated T-cell lymphoma (EATL); and 6 peripheral TCLs, not otherwise specified. All patients showed masslike lesions by clinical evaluations. Seven patients had abnormal CBC findings, including 6 anemia, 2 thrombocytopenia, and 2 leukopenia. TCR gene rearrangement studies were performed in 5 patients and all were positive for monoclonal TCR-γ. No patients showed concurrent bone marrow or lymph node involvement by either pathology and/or clinical studies. Four patients received chemotherapy. Five patients had no chemotherapy; 3 had a surgical procedure and 2 had conservative management only. Two patients died of disease and 7 patients were in remission or alive with disease.

Conclusions: Extranodal noncutaneous TCLs are more likely to be localized disease without systemic involvement. Anemia was the most common abnormal CBC finding, followed by thrombocytopenia and leucopenia. Clinical management is more variable with fewer patients receiving chemotherapy. Surgical treatment alone and conservative management were the treatment of choice in more patients with relatively favorable clinical outcome.

Volume

142

Issue

9

First Page

e62

Comments

American College of Pathologists Annual Meeting, October 20-24, 2018, Chicago, IL

Last Page

e62

DOI

10.5858/arpa.2018-0293-AB

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