Primary bladder signet ring cell adenocarcinoma in a young male with Lynch Syndrome.

Document Type

Article

Publication Date

9-25-2025

Publication Title

Urology case reports

Abstract

A 32-year-old male with Lynch Syndrome and a history of colon cancer status post total proctocolectomy was found to have invasive high-grade carcinoma with signet ring cell morphology on tissue sampling of the bladder neck following transurethral resection of a bladder tumor (TURBT). The patient subsequently underwent an open cystoprostatectomy and completion proctectomy. Final pathology of the prostate, bladder, and bladder augment confirmed the diagnosis of signet ring cell adenocarcinoma (SRCC) of the bladder. Given its rarity, this case illustrates the challenges of managing an aggressive bladder cancer and underscores the importance of considering appropriate screening strategies in high-risk populations.

Volume

63

First Page

103223

DOI

10.1016/j.eucr.2025.103223

ISSN

2214-4420

PubMed ID

41069686

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