Baseline Differences in Patient-Reported Quality of Life Across Breast Cancer Surgical Pathways.

Document Type

Article

Publication Date

9-30-2026

Publication Title

Annals of surgical oncology : the official journal of the Society of Surgical Oncology

Abstract

BACKGROUND: Advancements in breast cancer treatment have led to excellent survival outcomes, shifting focus toward patient-centered measures. Although patient-reported outcomes (PROs), particularly the BREAST-Q

METHODS: We performed a prospective cohort study of women aged ≥ 18 years with newly diagnosed stage I-III disease undergoing surgery from 2017 to 2024. Participants completed preoperative BREAST-Q

RESULTS: In total, 561 patients completed preoperative surveys. Significant baseline differences in PROs were observed across groups. On univariate analysis, all PRO domains except physical chest well-being differed significantly by procedure type. Multivariable analysis demonstrated that lower preoperative breast satisfaction and sexual well-being scores were associated with lumpectomy with oncoplastic reduction mammoplasty, bilateral mastectomy with reconstruction, and UMR compared with lumpectomy. Lower physical chest wall well-being was associated with unilateral mastectomy, and lower psychosocial well-being was associated with UMR.

CONCLUSION: Significant preoperative differences in PROs exist across procedures. Incorporating PRO measures into preoperative evaluation may improve shared decision-making and individualized patient care.

DOI

10.1245/s10434-026-20617-0

ISSN

1534-4681

PubMed ID

42816696

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