Shift in the urinary metabolome associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin activation of the hepatic aryl hydrocarbon receptor.

Document Type

Article

Publication Date

7-18-2025

Publication Title

Scientific reports

Abstract

Epidemiological evidence suggests an association between dioxin and dioxin-like compound (DLC) exposure and human liver disease. In rodents, the prototypical DLC, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has been shown to induce the progression of reversible hepatic steatosis to steatohepatitis with periportal fibrosis and biliary hyperplasia. Although the effects of TCDD are mediated by aryl hydrocarbon receptor (AHR) activation, the underlying mechanisms of induced pathologies have not been resolved. In the present study, male C57BL/6NCrl mice were gavaged every 4 days for 28 days with 0.03-30 μg/kg TCDD or sesame oil vehicle and evaluated for liver histopathology and gene expression as well as complementary 1-dimensional proton magnetic resonance (1-D

Volume

15

Issue

1

First Page

26035

DOI

10.1038/s41598-025-11772-7

ISSN

2045-2322

PubMed ID

40676134

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