First Clinical Implementation of Step-and-Shoot Proton Arc Therapy for Head and Neck Cancer Treatment.

Document Type

Article

Publication Date

6-1-2025

Publication Title

International journal of particle therapy

Abstract

PURPOSE: Dynamic Spot-scanning Proton Arc (SPArc

PATIENTS AND METHODS: An in-house spot and energy-layer sparsity optimization algorithm was integrated into a clinical treatment planning system. The algorithm prioritized higher MU-weighted energy layers and spots to ensure delivery efficiency and superior plan quality while meeting machine requirements (≥0.02MU/spot). A Dynamic SPArc simulator calculated delivery times, and a machine-learning-based synthetic CT(synCT) platform monitored dose robustness. In June 2024, a head-neck cancer patient with parotid gland malignancy was treated using SPArc

RESULTS: SPArc

CONCLUSION: The SPArc

Volume

16

First Page

100749

DOI

10.1016/j.ijpt.2025.100749

ISSN

2331-5180

PubMed ID

40474940

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