Mucinous Adenocarcinoma Arising From Teratoma Years After Testicular Nonseminomatous Germ Cell Tumor.

Authors

Hoon Oh, Oakland University William Beaumont School of Medicine Medical Student
Neud Kiros, Corewell Health East Resident
Sayf Al-Katib, Corewell Health East

Document Type

Article

Publication Date

9-10-2025

Publication Title

Cureus

Abstract

Growing teratoma syndrome (GTS) is a rare complication of nonseminomatous germ cell tumors (NSGCTs). We present a case of a patient with a remote history of NSGCT, previously treated with orchiectomy and chemotherapy, who developed a large retroperitoneal mass over two decades later. The patient had normal tumor markers and multiple inconclusive biopsies. Surgical excision was performed, and the pathology returned as mucinous adenocarcinoma arising within a teratoma. This case highlights both the critical importance of long-term surveillance following NSGCT and the need for complete surgical resection of residual teratomatous disease even years after initial treatment due to the risk of delayed malignant transformation.

Volume

17

Issue

9

First Page

e91983

Last Page

e91983

Recommended Citation

Oh H, Kiros N, Al-Katib S. Mucinous adenocarcinoma arising from teratoma years after testicular nonseminomatous germ cell tumor. Cureus. 2025 Sep 10;17(9):e91983. doi: 10.7759/cureus.91983. PMID: 41080297.

DOI

10.7759/cureus.91983

ISSN

2168-8184

PubMed ID

41080297