A novel lattice technique via adaptive spot assignment and LET optimization based proton arc therapy.

Document Type

Article

Publication Date

8-15-2026

Publication Title

International journal of radiation oncology, biology, physics

Abstract

PURPOSE: Lattice radiation therapy is an innovative three-dimensional implementation of spatially fractionated radiation therapy. This study aimed to develop a novel lattice-based proton arc therapy (PAT) technique to deliver a highly modulated peak-valley spatial dose distribution and a modulated linear energy transfer (LET) distribution.

METHODS AND MATERIALS: We introduced a PAT lattice algorithm that optimizes three key components, including energy-layer selection, spot assignment, and LET optimization (PAT

RESULTS: Compared with PAT

CONCLUSIONS: A novel PAT lattice technique using adaptive spot assignment and LET optimization could deliver an enhanced peak-valley spatial dose distribution. Experimental validation on a clinical proton system confirmed deliverability and dosimetric accuracy, which may facilitate future clinical translation of proton lattice radiotherapy.

Volume

S0360-3016

Issue

26

First Page

04147-7

DOI

10.1016/j.ijrobp.2026.07.051

ISSN

1879-355X

PubMed ID

42603564

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