Limitations in the Application of Clinicopathologic Factors Alone in Predicting Radiation Benefit for Women with Low-Risk Ductal Carcinoma in Situ after Breast Conserving Surgery: The Impact of a 7-gene Biosignature based on 10-Year Ipsilateral Breast Recurrence (IBR) Rates.

Document Type

Article

Publication Date

7-18-2025

Publication Title

International journal of radiation oncology, biology, physics

Abstract

Clinicopathologic (CP) factors are used to estimate 10-year ipsilateral breast recurrence (IBR) risk and inform shared decision-making regarding post-operative radiation treatment (RT) for ductal carcinoma in situ (DCIS) patients. This study assesses the clinical value of the 7-gene biosignature (Lab-Location) compared to traditional CP definitions for predicting IBR rates and RT benefit. DCIS patients (n=926) treated with breast conserving surgery (BCS) ±RT were categorized as CP low-risk or high-risk based on established CP factors, study criteria, and nomograms. Women were classified as molecular Low Risk or High Risk by the biosignature. Ten-year IBR rates for CP risk groups were compared to and stratified by the biosignature. There were 37% of women classified as molecular Low Risk by the biosignature, while on average 47% were classified as low-risk by various CP definitions (range: 35-60%). Overall, CP low-risk groups had a mean absolute IBR benefit with RT of 6% (HR, 0.46; p< .001). The biosignature reclassified 53% of CP low-risk patients to molecular High Risk. These reclassified patients experienced higher IBR rates when RT was omitted and benefited from RT (HR, 0.30; p< .001) with an absolute reduction of 11.6% (17.7% vs. 6.1%). CP low-risk patients with concordant biosignature Low Risk demonstrated no significant RT benefit. On average, 28% of high-risk CP patients were reclassified as biosignature Low Risk and had no significant RT benefit (5.9% vs. 4.0%). This observational study supports optimizing de-escalation/escalation treatment strategies for DCIS, the 7-gene biosignature reliably discriminated a low-risk group without significant RT benefit compared to CP factors alone and an elevated risk group that benefitted from RT, facilitating improved shared decision making. A randomized clinical trial (NRG CC-016) will provide Level 1A evidence for the impact of RT treatment on IBR rates for patients in the 7-gene biosignature Low Risk group, including those with CP high-risk.

Volume

Online ahead of print

DOI

10.1016/j.ijrobp.2025.07.1411

ISSN

1879-355X

PubMed ID

40685017

Link to Full Text

Share

COinS