Large Pleuropulmonary Blastoma Mimicking Congenital Pulmonary Airway Malformation in an Infant: A Case Report.

Authors

• Katherine Safsten Bekker, Michigan State University College of Human Medicine Medical Student
• Alyssa M. Gill, Michigan State University College of Human Medicine Medical Student
• James M. Decou, Corewell Health West
• David J. Hoogstra, Corewell Health West
• Erica Michiels, Corewell Health West

Document Type

Article

Publication Date

3-2026

Publication Title

Respiratory Medicine Case Reports

Abstract

Pleuropulmonary blastoma (PPB) is a rare pediatric lung malignancy that primarily involves the lungs and pleura. PPB can be easily misdiagnosed as congenital pulmonary airway malformation (CPAM) based on its cystic features. We report the case of an infant who presented to the emergency department with fever and respiratory distress. The patient tested positive for COVID-19, and imaging was initially suggestive of large CPAM in the right hemithorax causing compression of the right lung and midline shift to the left. Imaging also showed two hypodense lesions, one on the upper pole of the right kidney and the other on the right lobe of the thyroid. Prompt surgical removal of the lung lesion was indicated given the patient's worsening respiratory status and increasing mediastinal shift. Following thoracoscopic resection, histopathologic testing indicated PPB type 1r with

Volume

61

First Page

102400

Last Page

102400

Recommended Citation

Bekker KS, Gill AM, Decou JM, Hoogstra DJ, Michiels E. Large pleuropulmonary blastoma mimicking congenital pulmonary airway malformation in an infant: A case report. Resp Med Case Rep. 2026;61:102400. doi: 10.1016/j.rmcr.2026.102400. PMID: 42004637.

Comments

Helen DeVos Children's Hospital

DOI

10.1016/j.rmcr.2026.102400

ISSN

2213-0071

PubMed ID

42004637