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Description

Acute kidney injury (AKI) is a sudden decrease in kidney function that can lead to fluid imbalance and waste accumulation. AKI is a significant clinical challenge, particularly in pediatric patients, where AKI can lead to longterm consequences like chronic kidney disease. A key cause of AKI is exposure to nephrotoxic medications. The incidence of nephrotoxic-induced AKI is notably high in hospitalized children, with studies indicating that up to 86% of pediatric patients are exposed to at least one nephrotoxic medication during their stay.1 Nephrotoxic-induced AKI can lead to increase length of stay, cost of care, and higher morbidity and mortality rates.1,2 Given these risks, it is essential to understand the impact of nephrotoxic medications have on kidney function during hospitalization in the pediatric population. We hypothesize that nephrotoxic AKI is an underrecognized condition, with patients not being adequately evaluated for AKI following exposure to three or more nephrotoxic medications, despite the increased risk. Thus, we suspect that medication-induced AKI in hospitalized pediatric patients at Corewell Health is significant, yet underreported due to insufficient creatinine monitoring after medication exposure.

Publication Date

5-2025

Keywords

Acute kidney injury

Comments

The Embark Capstone Colloquium at the Oakland University William Beaumont School of Medicine, Rochester Hills, MI, May, 2025.

Nephrotoxic Medication Induced Acute Kidney Injury in Hospitalized Pediatric Patients

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