Newborn Screening Reduces Survival Disparities in SCID after Stem Cell Transplant: A PIDTC Report.

Authors

• Lena E Winestone
• Brent R Logan
• Xuerong Liu
• Olatundun Williams
• Elizabeth A Dunn
• Monica S Thakar
• Sharon A Kidd
• Talal Mousallem
• Morna J Dorsey
• Troy C. Quigg, Corewell Health West

Document Type

Article

Publication Date

7-2026

Publication Title

Journal of Human Immunology

Abstract

Black race and Hispanic ethnicity are associated with higher mortality in severe combined immunodeficiency (SCID) following hematopoietic cell transplantation (HCT), though mechanisms remain unclear. We evaluated 796 children with SCID who received nonsibling HCT between 1982 and 2020 using data from the Primary Immune Deficiency Treatment Consortium. Overall survival for Black (aHR 2.47, 95%CI 1.64, 3.71) and Asian/Pacific Islander patients (aHR 1.82, 95%CI 1.00, 3.30) was significantly lower compared with non-Hispanic White patients, while Hispanic patients had lower event-free survival (aHR 1.83, 95%CI 1.27, 2.63) compared with non-Hispanic White patients. Even after adjusting for age and infection, Black patients with SCID had more than twofold hazard of death compared with non-Hispanic White patients. NBS was associated with earlier diagnosis, reduced infection at HCT, and elimination of survival disparities between Black and non-Hispanic White patients. These findings suggest that universal, system-level interventions such as NBS can mitigate disparities in outcomes for children with SCID.

Volume

2

Issue

5

First Page

e20250231

Last Page

e20250231

Recommended Citation

Winestone LE, Logan BR, Liu X, Williams O, Dunn EA, Thakar MS, et al. [Quigg TC]. Newborn screening reduces survival disparities in SCID after stem cell transplant: A PIDTC report. Journal of human immunity. 2026;2(5):e20250231. doi: 10.70962/jhi.20250231. PMID: 42416786.

Comments

Helen DeVos Children's Hospital

DOI

10.70962/jhi.20250231

ISSN

3065-8993

PubMed ID

42416786