Evaluating the G-ROP Criteria Sensitivity for Type 1 ROP in a North American Cohort.

Document Type

Article

Publication Date

11-2025

Publication Title

Journal of AAPOS

Abstract

BACKGROUND: Current screening criteria for retinopathy of prematurity (ROP) follow the American Academy of Pediatrics (AAP) guidelines. However, the Postnatal Growth and Retinopathy (G-ROP) study has proposed newer criteria, showing 100% sensitivity for detecting type 1 ROP while reducing the number of infants requiring dilated retinal examinations by 30%. The purpose of this study was to validate the G-ROP criteria in a midsized Midwestern children's hospital.

METHODS: We conducted a retrospective cohort study of infants screened for ROP between January 2018 and December 2022 under AAP guidelines. We then applied the G-ROP criteria to the same cohort and evaluated the sensitivity and specificity of these guidelines for detecting type 1 ROP requiring treatment.

RESULTS: A total of 687 infants were included. The average gestational age 28 weeks; the average birthweight, 1022.5 g. Of the 687 infants screened by standard of care (SOC) criteria, 448 (65.2%) met G-ROP criteria. Using SOC criteria, 34 infants (4.9%) developed type 1 ROP necessitating treatment. However, when using G-ROP screening criteria, 33 of 448 (7.4%) with type 1 ROP were identified. The sensitivity of G-ROP for detecting type 1 ROP was 97.1%, but 1 infant who required treatment was missed.

CONCLUSIONS: G-ROP criteria demonstrated high sensitivity but did not match the 100% sensitivity from earlier studies. The single infant with type 1 ROP missed by G-ROP screening had a medical history of twin-to-twin transfusion syndrome. The physiologic factors of twin-to-twin transfusion syndrome could be important to explore when considering ROP screening criteria.

First Page

104694

Last Page

104694

Comments

Helen DeVos Children's Hospital

DOI

10.1016/j.jaapos.2025.104694

ISSN

1528-3933

PubMed ID

41274541

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