Clinicopathologic Features, Management, and Outcomes Of Pediatric CRTC1::TRIM11 and MED15::ATF1 Tumors With Spitzoid Morphology: A Case Series.

Authors

Michael R Sargen
Madeline H Fitzhugh
Jennifer S Ko
Allison G. Close, Corewell Health West
Sara C Horton
Faizan Malik
Larissa V Furtado
Armita Bahrami
Brittani K N Seynnaeve
Alberto S Pappo
Kristen G Berrebi

Document Type

Article

Publication Date

2025

Publication Title

Pediatric Blood & Cancer

Abstract

Limited information is available on the clinicopathologic features and management of pediatric CRTC1::TRIM11 (CTRTs) and MED15::ATF1-rearranged tumors (MARTs). In this series of pediatric CTRTs (n = 5) and MARTs (n = 2), all tumors exhibited spitzoid morphology and expressed melanocytic markers. Metastatic progression occurred in one CTRT and two MARTs: all three received immunotherapy, resulting in disease control in two patients and one death due to progressive disease. A fourth individual had lymph node micrometastasis that remained stable without progression. This case series highlights the potentially aggressive behavior of these tumors and suggests that immunotherapy may be an effective treatment option for advanced disease.

Volume

72

Issue

8

First Page

31814

Last Page

31814

Recommended Citation

Sargen MR, Fitzhugh MH, Ko JS, Close AG, Horton SC, Malik F, et al. Clinicopathologic features, management, and outcomes of pediatric CRTC1::TRIM11 and MED15::ATF1 tumors with spitzoid morphology: A case series. Pediatr Blood Cancer. 2025:919-28.e1. doi: 10.1002/pbc.31814. PMID: 40390195.

Comments

Helen DeVos Children's Hospital

DOI

10.1002/pbc.31814

ISSN

1545-5017

PubMed ID

40390195