Kidney Injury Molecule-1 Is a Useful Marker to Detect Renal Cell Carcinoma

Document Type

Conference Proceeding

Publication Date

9-2019

Publication Title

Archives of Pathology and Laboratory Medicine

Abstract

Context: We have previously reported that kidney injury molecule-1 (KIM-1) stains positively in clear cell renal cell carcinoma (RCC) and papillary RCC. Additionally, we have shown RCC patient’s urine levels of KIM-1 are elevated before surgery and reduced after nephrectomy. High serum KIM-1 in patients with RCC is reported to predict patients’ development of RCC within 5 years. Design: We reviewed the serum levels of KIM-1 in 10 patients with localized RCC that stained positively for KIM-1 and demonstrated increased urine KIM-1. We compared those results with the serum and urine KIM-1 results of 3 patients with benign renal lesions after nephrectomy. Lastly, we stained 8 cases with metastatic RCC for KIM-1 and Pax8. Results: We found that 7 of 10 patients (70%) with localized RCC had increased serum KIM-1, up to 100-fold higher than reference range serum level. After nephrectomy, 5 available RCC cases had reduced serum KIM-1. By contrast, only 1 of 3 controls was found to have reduced serum KIM-1 after nephrectomy. In cases with metastatic RCC, KIM-1 stained positively in 7 of 8 cases (88%), whereas PAX8 was positive in 5 of 8 cases (62%). Conclusions: KIM-1 staining may be a valuable marker in identifying metastatic RCC, in combination with PAX8. In addition, our serum data for KIM-1 were consistent with findings of high serum KIM-1 levels in patients with RCC from the recent Center for Cancer Research (National Cancer Institute, Bethesda, Maryland) study, implying its usefulness in detecting recurrent or metastatic RCC.

Volume

143

Issue

9

First Page

e93

Comments

College of American Pathologists Annual Meeting, September 21-25, 2019, Orlando, FL

Last Page

e93

DOI

10.5858/arpa.2019-0901-AB

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