Concurrent Immune Complex Glomerulonephritis and Anti-Neutrophil Cytoplasmic Antibodies-Associated Crescentic Glomerulonephritis

Document Type

Conference Proceeding

Publication Date

1-2018

Publication Title

American Journal of Clinical Pathology

Abstract

Objective: Alteration in the immune system may be associated with immune complex mediated glomerulonephritis (GN) and/or other kidney diseases. Methods and Materials: Here we report a small unusual series of immune complex diseases membranoproliferative glomerulonephritis (MPGN) and post-infectious glomerulonephritis (post-IGN) coexisting with possible anti-neutrophil cytoplasmic antibodies (ANCAs)- associated glomerulonephritis (GN). Results: The first case is a 66-year-old man (M), positive ANCA at 1:80, serum creatinine (sCr) 1.72 mg/dL with 19% crescents in glomeruli and type 3 MPGN. The second case is a 55-year-old woman (F), positive ANCA at 1:40, sCr 4.87  mg/dL with 28% of crescents in glomeruli and type 1 MPGN. The third case is a 75-year-old F, positive ANCA at 1:160, sCr 3.86 mg/dL with 25% crescents in glomeruli and type 1 MPGN. The fourth case is a 76-year-old F, positive ANCA at 1:160, sCr 6.27  mg/ dL with 66% crescents in glomeruli and post-IGN. The fifth case is a 63-year-old M, ANCA 1:640, sCr 4.4 mg/dL with 78% crescents in glomeruli and post-IGN. The sixth case is a 62year-old M, positive ANCA at 1:640 and sCr 6.71 mg/dL with 53% crescents in glomeruli and MPGN type 1. Conclusion: The high percent of crescentic glomeruli cannot be explained by the relatively minor immune complex diseases but by positive ANCA; we therefore consider that the GNs most likely result from positive ANCA rather than being secondary to the immune complex-mediated GN.

Volume

149

Issue

Suppl 1

First Page

S100

Comments

American Society for Clinical Pathology (ASCP) Annual Meeting, November 2-5, 2017, Kissimmee, FL

Last Page

S100

DOI

10.1093/ajcp/aqx123.233

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