Assessing the Effects of Antidepressant Use on Stroke Recurrence and Related Outcomes in Ischemic Stroke Patients: A Propensity Score Matched Analysis

Authors

• Faisal F Alamri
• Daniyah A Almarghalani
• Yasser Alatawi
• Eman A Alraddadi
• Omar Babateen
• Ahmed Alayyafi
• Ziyad Almalki
• Khaled Alsalhi
• Khaled Alzahrani
• Ahmed Alghamdi
• Hussain Aldera
• Vardan T Karamyan, Oakland University William Beaumont School of Medicine Faculty

Document Type

Article

Publication Date

1-1-2025

Publication Title

Front Pharmacol

Abstract

The effect of antidepressant use, particularly that of selective serotonin reuptake inhibitors, on stroke outcomes remains unclear. This hospital-based, retrospective, observational study utilized propensity score-matching (PSM) to assess the association between antidepressant use, stroke-related outcomes, and complications. The study was conducted at King Abdulaziz Medical City (KAMC) in Jeddah and Riyadh and included 1,125 patients with acute-subacute ischemic stroke, of whom 1,025 were antidepressant non-users and 100 antidepressant users. After PSM, 200 patients (100 antidepressant users and 100 non-users) were included in the final analysis. This study aimed to assess the association between antidepressant use, stroke recurrence, and mortality. Additionally, the study examined the association between antidepressant use and stroke severity, functional independence, and incidence of post-stroke complications. The Kaplan-Meier analysis revealed no statistically significant differences in stroke recurrence (

Volume

16

First Page

1558703

Last Page

1558703

Recommended Citation

Alamri FF, Almarghalani DA, Alatawi Y, et al. Assessing the effects of antidepressant use on stroke recurrence and related outcomes in ischemic stroke patients: a propensity score matched analysis. Front Pharmacol. 2025;16:1558703. Published 2025 Mar 12. doi:10.3389/fphar.2025.1558703

DOI

10.3389/fphar.2025.1558703

ISSN

1663-9812

PubMed ID

40144654