NPY Y NPY Y1 and Y2 receptors in the regulation of mouse recognition and procedural memory: Interplay with cellular signalling, noradrenergic transmission and monoamine concentrations.

Document Type

Article

Publication Date

5-1-2026

Publication Title

British journal of pharmacology

Abstract

BACKGROUND AND PURPOSE: Recognition and procedural memory are modulated by the noradrenergic system, whose terminals release noradrenaline along with neuropeptide Y, acting via Y1 and Y2 receptors. This study aims to investigate the role of Y1 and Y2 receptor antagonists (BMS-193885 and SF-11) on recognition and procedural memory, including their co-administration with clenbuterol, a β

EXPERIMENTAL APPROACH: Recognition memory was assessed in mice using the novel object recognition task. Motor learning and procedural memory were evaluated in the accelerating rotarod test. Memory-related behavioural outcomes were complemented by analyses of NPY levels, the phosphorylation status of CaMKII and ERK1/2, along with the concentrations of 5-HT, dopamine, noradrenaline and its metabolite in selected brain regions, including the prefrontal cortex, hippocampus and cerebellum.

KEY RESULTS: SF-11 at 5 mg·kg

CONCLUSIONS AND IMPLICATIONS: NPY receptor antagonists modulate memory processes in a dose- and memory-type-dependent manner, and these effects appear to be linked to hippocampal function. NPY receptors may serve as therapeutic targets to treat cognitive impairments.

Volume

183

Issue

9

First Page

1958

Last Page

1974

DOI

10.1111/bph.70287

ISSN

1476-5381

PubMed ID

41360393

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