Targeting Pericyte Retention in Diabetic Retinopathy: A Review.

Document Type

Article

Publication Date

12-1-2024

Publication Title

Annals of medicine

Abstract

Diabetic retinopathy is a common yet severe complication of diabetes mellitus and is the leading cause of blindness in middle-aged adults. After years of poorly managed hyperglycemia, complications begin as non-proliferative diabetic retinopathy but can then progress into the proliferative stage marked by neovascularization of the retina. Multiple pathologic mechanisms caused by chronic hyperglycemia damage the retinal vasculature leading to pericyte drop out and the progression of the disease. This review outlines the major pathways of pathogenesis in diabetic retinopathy, highlighting the protective role pericytes play in preserving the blood-retinal barrier. Given the loss of this cell line is a defining feature of the disease, ways in which to prevent pericyte dropout within retinal vasculature is discussed, targeting various pathogenesis pathways of diabetic retinopathy.

Volume

56

Issue

1

First Page

2398200

Last Page

2398200

DOI

10.1080/07853890.2024.2398200

ISSN

1365-2060

PubMed ID

39268600

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