Surgical Outcomes of Retinal Detachment in Cytomegalovirus Retinitis: A 10-Year Single-Center Study

Document Type

Conference Proceeding

Publication Date

6-2025

Publication Title

Investigative Ophthalmology and Visual Science

Abstract

Purpose : This study evaluates the clinical characteristics, surgical techniques, and outcomes of retinal detachment (RD) associated with cytomegalovirus (CMV) retinitis.

Methods : This was a retrospective, longitudinal case series. Patients with polymerase chain reaction (PCR)-confirmed CMV retinitis who underwent vitreoretinal surgery for CMV-related RD at Bascom Palmer Eye Institute from 2014 to 2024 were included and clinical records were reviewed. Statistical analyses included Fisher's exact test, and Mann-Whitney Wilcoxon tests. The primary outcomes were single-surgery anatomic success and visual acuity (VA) >20/400 at last followup.

Results : Seventeen patients (mean age: 49.53 ± 14.5 years; 7/17 (41.17%) female) with CMV retinitis and RD were included in this study. Of these, 11/17 (64.70%) were HIV-positive. RD involving more than two quadrants was observed in 10/17 (58.82%, IQR: 2–4) patients, and macula-off RD was noted in 13/17 (76.47%) of patients. The mean preoperative VA was 0.9 logMAR (Snellen:20/158). The mean interval from presentation to RD diagnosis was 72.65 ± 157.1 days (IQR: 0–37.5). Prior to surgery, all patients (17/17, 100%) had received oral antiviral therapy, and 16/17 (94.11%) had undergone intravitreal antiviral treatment. Pars plana vitrectomy (PPV) was performed in all cases, with scleral buckling and silicone oil tamponade utilized in 12/17 (70.58%) and 16/17 (94.11%) patients, respectively. The mean interval from RD diagnosis to surgery was 9.62 ± 15.63 days (IQR: 1–12.5). Mean follow-up duration was 21.34 ± 26.70 months. Single-surgery success was achieved in 88.23% (15/17) of patients, with two cases of recurrent RD. At the final follow-up, 13/17 (76.47%) patients attained VA >20/400, and 8/17 (47.06%) achieved VA >20/200. No independent predictors of VA >20/400 were identified.

Conclusions : In conclusion, modern vitreoretinal surgical techniques demonstrate high single-surgery anatomic success and favorable visual outcomes for CMV-related RD.

Volume

66

Issue

8

First Page

224

Comments

Association for Research in Vision and Ophthalmology ARVO Annual Meeting, May 4-8, 2025, Salt Lake City, UT

Last Page

224

Link to Full Text

Share

COinS