Development of Norrin-Based Protein Therapeutic for Activation of Norrin-Wnt Signaling in Human Retinal Endothelial Cells.

Authors

• Kenneth P. Mitton
• Wendy A. Dailey
• Steven Q. Krikor
• Kimberly A. Drenser, Corewell Health East

Document Type

Article

Publication Date

11-24-2025

Publication Title

Int J Mol Sci

Abstract

Norrin-Wnt signaling is essential for retinal vascular development and generation of the inner blood retinal barrier. Norrin itself is a potential therapeutic for retinal vascular repair. We explored the feasibility of producing a recombinant protein therapeutic based on human Norrin for intravitreal injection. Norrin

Volume

26

Issue

23

First Page

11340

Recommended Citation

Mitton KP, Dailey WA, Krikor SQ, Drenser KA. Development of Norrin-Based Protein Therapeutic for Activation of Norrin-Wnt Signaling in Human Retinal Endothelial Cells. Int J Mol Sci. 2025 Nov 24;26(23):11340. doi: 10.3390/ijms262311340. PMID: 41373499; PMCID: PMC12692543.

DOI

10.3390/ijms262311340

ISSN

1422-0067

PubMed ID

41373499