Comorbid Depression and Anxiety Risk in Older Individuals with Geographic Atrophy: A US Claims Data Analysis.

Document Type

Article

Publication Date

6-11-2025

Publication Title

Advances in therapy

Abstract

INTRODUCTION: Geographic atrophy (GA), an advanced stage of nonexudative age-related macular degeneration (AMD), is associated with progressive central vision loss and blindness. While the association between GA and impaired vision-related quality of life has been established, understanding of the co-occurrence of anxiety and depression in individuals with GA is limited.

METHODS: We conducted a retrospective, noninterventional, cohort study analyzing data from three large US databases (Optum's de-identified Clinformatics

RESULTS: The Clinformatics

CONCLUSION: This study found a higher risk for comorbid depression or anxiety in patients with GA versus propensity score-matched controls. Risk was greatest among those with bilateral GA with subfoveal involvement. These findings highlight the important mental health burden experienced by patients with GA.

Volume

Online ahead of print

DOI

10.1007/s12325-025-03219-2

ISSN

1865-8652

PubMed ID

40498279

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