A Case of Uveal Melanoma Masquerading as Choroidal Lymphoma.
Document Type
Article
Publication Date
5-1-2026
Publication Title
Retin Cases Brief Rep
Abstract
PURPOSE: To present a case of uveal melanoma masquerading as choroidal lymphoma.
METHODS: A retrospective case report in which medical and imaging records, including fundus photography, optical coherence tomography, fundus autofluorescence, fluorescein angiography, and ultrasonography were reviewed.
RESULTS: A 77-year-old woman presented with decreased vision was found to have a diffuse, shallow, yellow choroidal mass associated with RPE pigmentary changes and exudative detachment in her right eye. Multi-modal imaging demonstrated thickened choroid with a "lumpy-bumpy" appearance on OCT, "leopard-spotting" on fundus autofluorescence, and a shallow "table-top" configuration on B scan. Systemic workup was unremarkable. The patient elected to undergo treatment with low-dose external beam radiation for presumed choroidal lymphoma. There was no response to radiation prompting retinochoroidal biopsy, which revealed spindle-cell uveal melanoma and resulted in enucleation.
CONCLUSION: We present a case of uveal melanoma masquerading as choroidal lymphoma. This case highlights that uveal melanoma can rarely masquerade as other entities, including uveal lymphoma.
Volume
20
Issue
3
First Page
364
Last Page
368
Recommended Citation
Saleh SH, Stepanian R, Juliano JD, Folberg R, Laurie LS, Faia LJ, Weiner AJ. A Case of uveal melanoma masquerading as choroidal lymphoma Retin Cases Brief Rep. 2026 May 1;20(3):364-368. doi: 10.1097/ICB.0000000000001738. PMID: 39983096.
DOI
10.1097/ICB.0000000000001738
ISSN
1937-1578
PubMed ID
39983096