Efficacy and Safety of Radiosurgery in Cavernous Sinus Meningioma: A Systematic Review and Single Meta-Analysis.

Document Type

Article

Publication Date

11-2025

Publication Title

Neurosurgery Practice

Abstract

BACKGROUND AND OBJECTIVES: Meningiomas are the most common primary central nervous system tumors, with cavernous sinus meningiomas (CSMs) making up a small fraction (1% of intracranial tumors). CSMs are challenging to treat due to their location and potential invasion. Therapy methods have shifted from aggressive resections to less invasive techniques such as stereotactic radiosurgery, reducing morbidity and improving survival. This study reviews the effectiveness and safety of radiosurgery for CSMs, blending historical and contemporary approaches to guide future treatments.

METHODS: A search was performed in MEDlINE, Embase, and Cochrane databases, following Cochrane and Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Eligible studies included randomized or observational studies with ≥4 patients reporting on radiosurgery for CSM. The random-effects model was used to calculate a single proportion analysis with 95% CIs. Statistical analyses were performed using RStudio.

RESULTS: Twenty seven studies, encompassing 1851 patients, were included in this analysis, with a population median age of 27 years. Outcomes were assessed as follows: the 10-year progression-free survival rate was 87% (323 patients; 95% CI: 73%-100%; I

CONCLUSION: This study reveals stereotactic radiosurgery as an effective treatment of CSMs, showing high long-term progression-free survival and significant tumor control with few complications.

Volume

6

Issue

4

First Page

e000187

Last Page

e000187

DOI

10.1227/neuprac.0000000000000187

ISSN

2834-4383

PubMed ID

41200535

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