Responsive Neurostimulation (RNS) Programming.

Document Type

Article

Publication Date

6-2026

Publication Title

Neurotherapeutics

Abstract

Programming of RNS is an iterative process involving a logical progression of patient-specific electrocorticographic biomarker detections that inform stepwise progression of stimulation parameters. In this paper, we discuss the identification and detection of specific pro-ictal, pre-ictal, ictal onset, and seizure body biomarkers as they relate to optimal timing of neurostimulation. General principles underlying different stimulation paradigms are reviewed, and a practical progression of stimulation paradigms is presented with the goals of maximizing the acute seizure-disruptive effects of stimulation as well as the long term neuromodulatory effects, which translate to sustained improvement in seizure frequency and severity.

Volume

23

Issue

4

First Page

e00944

Last Page

e00944

DOI

10.1016/j.neurot.2026.e00944

ISSN

1878-7479

PubMed ID

42302539

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