A Rare Case of Hemosuccus Pancreatitis Secondary to Hemorrhagic Pancreatitis

Document Type

Conference Proceeding

Publication Date

10-2025

Publication Title

American Journal of Gastroenterology

Abstract

Introduction: Hemosuccus pancreaticus (HP) is a rare cause of upper gastrointestinal bleeding (UGIB), defined as bleeding from the ampulla of Vater via the pancreatic duct. It occurs in 1 in 1500 UGIB cases and is usually seen with chronic pancreatitis-related pseudoaneurysms, pancreatic neoplasms, or trauma. We present a case of HP likely secondary to hemorrhagic pancreatitis, without the usual etiologies. Case Description/Methods: A 52-year-old man with alcohol use disorder and chronic pancreatitis was admitted for altered mental status and found to have severe alcohol-related hepatitis in the setting of decompensated cirrhosis. He reported melena and epigastric pain; vitals showed mild tachycardia and systolic blood pressure of 96 mmHg. Investigations showed hemoglobin 7.7 g/dL (baseline 9–10), lipase 24 U/L, AST 130 U/L, ALT 69 U/L, ALP 87 U/L, total bilirubin 22.2 mg/dL (direct >15), undetectable fecal elastase, and phosphatidylethanol .2000 ng/mL. He was started on intravenous pantoprazole. Esophageogastroduodenoscopy (EGD) revealed slow oozing at the papilla clearly originating from the pancreatic orifice as bile was seen flowing from biliary orifice, confirmed via duodenoscopy. Non-bleeding grade II esophageal varices were also noted and not banded. Computed tomography angiography showed distal pancreatitis with a 6 mm hyperenhancing lesion in the pancreatic tail on arterial phase. Given concern for pseudoaneurysm, invasive angiography was performed but showed no active bleed or pseudoaneurysm. Magnetic Resonance Cholangiopancreatography (MRCP) confirmed the computed tomography findings, showing multiple small hemorrhagic foci in the distal pancreatic tail, suggesting hemorrhagic pancreatitis. The bleeding was thought to be secondary to a small fistulous tract between the hemorrhagic foci and pancreatic duct. The patient was managed conservatively with resolution of melena. At follow-up, he reported continued alcohol abstinence and clinical improvement. Discussion: Hemorrhagic pancreatitis stems from enzymatic extravasation and erosion of local vessels, leading to UGIB. Although melena with heavy alcohol use is often due to peptic ulcer or portal hypertensive bleeding, rare cases can include HP due to hemorrhagic pancreatitis, especially when no clear source is found on EGD. A high index of suspicion and early use of computed tomography angiogram and MRCP can aid in early diagnosis and appropriate management. Angiographic embolization may be needed to prevent complications such as hemorrhagic shock and multi-organ failure.

Volume

120

Issue

10S2

First Page

S787

Comments

American College of Gastroenterology Annual Meeting, October 24-29, 2025, Phoenix, AZ

Last Page

S787

DOI

10.14309/01.ajg.0001142124.91723.2c

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