Long Term Mortality Trends in GI Neoplasms With Liver Metastases: Insight From CDC Data (1999-2020)

Document Type

Conference Proceeding

Publication Date

10-2025

Publication Title

American Journal of Gastroenterology

Abstract

Introduction: Gastrointestinal (GI) cancers cause significant cancer-related deaths worldwide, with liver metastases contributing heavily to mortality. This study analyzes mortality trends from 1999 to 2020. Methods: CDC WONDER mortality data (1999–2020) were retrospectively analyzed. Age-adjusted mortality rates (AAMRs) per 100,000 for liver metastasis were calculated. Trends were assessed by Annual Percent Change (APC), stratified by age, sex, race/ethnicity, and region. Results: Between 1999 and 2020, 201,843 deaths due to liver metastasis in GI neoplasm patients aged ≥25 were recorded in the U.S. Joinpoint regression showed a steady decline in AAMR from 1999 to 2008 (APC: -6.3171; 95% CI: 6.85–5.89), followed by a sharp increase from 2016 to 2020 (APC: 4.85; 95% CI: 3.15–5.74). Men had higher mortality increases (APC: 4.99; 95% CI: 3.25–6.00) than women (APC: 4.37; 95% CI: 1.70–5.65). By race/ethnicity, AAMR was highest among non-Hispanic Black/ African Americans (APC: 3.69; 95% CI: 2.31–5.86), followed by non-Hispanic Whites (APC: 5.43; 95% CI: 4.03–6.24), Hispanics/Latinos (APC: 5.52; 95% CI: 4.48–7.10), Asians/Pacific Islanders (APC: 7.65; 95% CI: 4.69–15.42), and American Indians/Alaskan Natives (APC: 5.63; 95% CI: 2.54–15.42). Regionally, the Midwest had the highest mortality increase (APC: 6.55; 95% CI: 3.86–8.23), followed by the West (APC: 1.59; 95% CI: 1.74–5.74), South (APC: 2.11; 95% CI: 1.47–4.53), and Northeast (APC: 9.00; 95% CI: 1.85–12.58). Non metropolitan areas showed higher mortality increases (APC: 7.19; 95% CI: 6.25–8.69) than metropolitan areas (APC: 3.85; 95% CI: 0.97–6.14). Conclusion: This study highlights a marked rise in liver metastasis-related mortality among U.S. adults with GI neoplasms since 2006. It underscores the need for targeted public health efforts to address disparities and improve outcomes in underserved populations.

Volume

120

Issue

10S2

First Page

S586

Comments

American College of Gastroenterology Annual Meeting, October 24-29, 2025, Phoenix, AZ

Last Page

S586

DOI

10.14309/01.ajg.0001138380.93166.35

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