Trends and Mortality Due to Malignant Neoplasms of the Endocrine Glands and Related Structures in the United States from 1999 to 2020 - A CDC Wonder Analysis

Document Type

Conference Proceeding

Publication Date

10-2025

Publication Title

Journal of the Endocrine Society

Abstract

Background: Malignant neoplasms of endocrine glands (thyroid, adrenal, endocrine pancreas, parathyroid, pituitary, pineal, aortic body, and carotid body) are rare but have distinct clinical presentations. This study analyzes mortality trends across epidemiological groups from 1999 to 2020. Methods: Using the CDC WONDER database (1999-2020), this study examines age-adjusted mortality rates (AAMR) per 1,000,000 individuals for ICD-10 codes C25.4 and C73-C75. Joinpoint regression (Version 5.3.0, National Cancer Institute) was applied to assess parallelism, Annual Percent Change (APC), and Average APC (AAPC) with a 95% confidence interval. Results: A total of 66,996 deaths were reported from 1999 to 2020. The AAMR increased slightly from 9.40 (1999) to 9.54 (2020) with an AAPC of 0.02 (95%CI, -0.15 to -0.19). The AAMR of males (9.46) was higher than females (8.40). Females showed a decrease with AAPC of -0.07(95%CI, -0.26 to 0.13). Males showed a significant decrease from 1999 to 2003 with APC of -2.54% (95%CI, -4.27 to -0.79, p=0.007) and then an increase until 2020 with APC of 0.45% (95% CI, 0.27 to 0.63, p=0.00006). West had the highest AAMR (9.88) followed by Midwest (9.49), Northeast (9.05) and South (8.67). A decreasing trend was observed in all regions except West which showed an increase with AAPC of 0.38 (95% CI, 0.15 to 0.62, p=0.003). Northeast showed the highest decrease with AAPC of -0.23 (95%CI, -0.58 to 0.13). AAMR was highest for whites (9.28) and lowest for Non-Hispanic (NH) Blacks (8.89). NH Blacks with AAPC of -0.32 (95%CI, -0.84 to 0.21) and Asians with AAPC of -0.43 (95%CI, -1.03 to 0.17) showed a decreasing trend but a slight increase was observed in Whites with AAPC of 0.07 (95%CI, -0.09 to 0.23). AAMR was highest for North Dakota (11.35) and lowest for Nevada (7.63). Crude rate was highest for 85+ years age group (87.49 per 1,000,000). People with age < 75 years showed a decrease, the 1-4 years age group showing the highest decrease with AAPC of -2.48 (95%CI, -3.07 to -1.89, p< 0.000001). Above 75, an increasing trend was observed with 85+ years showing AAPC of 1.38 (95%CI, 1.07 to 1.69, p< 0.000001). AAMR was higher in non-metropolitan areas (9.59) than in metropolitan (9.09). Metropolitan areas showed a decrease with AAPC of -0.28 (95%CI, -0.59 to 0.04) but a significant increase was observed in nonmetropolitan areas with AAPC of 0.55 (95% CI, 0.19 to 0.91, p=0.004).Conclusion: Despite advancements in technology, there is a slight increase in mortality from 1999 to 2020. Males, West, Whites, rural areas and 85+ age groups have shown an increasing mortality trend which underscores the need for tailored interventions to decrease mortality and disparities across various groups.

Volume

9

Issue

Suppl 1

First Page

A1312

Comments

ENDO 2025 Endocrine Society Annual Meeting, July 12-15, 2025, San Francisco, CA

Last Page

A1313

DOI

10.1210/jendso/bvaf149.2493

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