Impact of Steroids on Managing Iatrogenic Pericardial Diseases After Electrophysiological Procedures

Document Type

Conference Proceeding

Publication Date

4-2025

Publication Title

Heart Rhythm

Abstract

Background: Pericardial diseases are a recognized complication following electrophysiological (EP) procedures. While colchicine is a standard therapy, the potential benefits of adding steroids for iatrogenic pericardial diseases in the management remain unclear. Objective: We aimed to assess the impact of steroids on managing iatrogenic pericardial diseases after electrophysiological procedures. Methods: We utilized the TriNetX network to identify adult patients who had EP procedures and developed pericardial diseases (acute pericarditis/ pericardial effusion/ cardiac tamponade) within 1-month postprocedurally. Patients were categorized based on the use of steroids: steroids+ vs. steroids-. Those with a history of lupus or neoplasm were excluded. Patients were then followed for 1 year. Primary outcomes included all-cause mortality, all-cause hospitalization, and recurrence of significant pericardial diseases requiring interventions (pericardiocentesis, pericardiotomy). Results: After propensity score matching, 588 patients were included, with 294 patients in each cohort. Steroids+ group was associated with lower odds of recurrence of significant pericardial diseases requiring interventions (aOR 0.59, 95% CI 0.38–0.93, P50.02) than the steroids- group. There was no difference in the all-cause mortality (aOR 1.49, 95% CI 0.72–3.08, P50.28) and all-cause hospitalization (aOR 1.07, 95% CI 0.74–1.54). Conclusion: Steroids+ therapy in managing iatrogenic pericardial disease after EP procedures was associated with lower odds of recurrence of significant pericardial diseases.

Volume

22

Issue

4 Suppl

First Page

S333

Comments

Heart Rhythm Society Annual Meeting, April 24-27, 2025, San Diego, CA

Last Page

S333

DOI

10.1016/j.hrthm.2025.03.699

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