Cardiovascular Impact of Endovascular Revascularization in Chronic Limb-Threatening Ischemia Versus Claudication: A Contemporary Real-World Analysis.
Document Type
Article
Publication Date
4-23-2026
Publication Title
J Soc Cardiovasc Angiogr Interv
Abstract
BACKGROUND: Chronic limb-threatening ischemia (CLTI) represents the most severe form of peripheral artery disease, yet long-term cardiovascular outcomes after endovascular revascularization compared with claudication remain poorly defined.
METHODS: Using the TriNetX global research network (114 health care organizations), adults undergoing endovascular lower-extremity revascularization for CLTI or intermittent claudication were identified. Propensity score matching for demographics, comorbidities, and cardiovascular medications yielded 3727 matched pairs. Major adverse cardiovascular events (all-cause mortality, myocardial infarction, or stroke) and secondary outcomes were assessed at 1, 3, and 5 years.
RESULTS: At 5 years, patients with CLTI experienced a significantly higher risk of major adverse cardiovascular events compared with those with claudication (34.9% vs 30.7%;
CONCLUSIONS: Chronic limb-threatening ischemia patients undergoing endovascular revascularization experience significantly worse short- and long-term cardiovascular outcomes compared with claudication, underscoring the need for intensified cardiovascular risk stratification and secondary prevention in this high-risk population following peripheral intervention.
Volume
5
Issue
6
First Page
105372
Recommended Citation
Jahan S, Awad A, Al-Mollah M, Hussein M, Alwifati N, Sirajuddin K et al Cardiovascular impact of endovascular revascularization in chronic limb-threatening ischemia versus claudication: a contemporary real-world analysis. J Soc Cardiovasc Angiogr Interv. 2026 Apr 23;5(6):105372. doi: 10.1016/j.jscai.2026.105372. PMID: 42516853
DOI
10.1016/j.jscai.2026.105372.
ISSN
2772-9303
PubMed ID
42516853