Cardiovascular Outcomes After Percutaneous Coronary Intervention in Patients With Serious Mental Illness.

Document Type

Article

Publication Date

7-10-2026

Publication Title

International journal of psychiatry in medicine

Abstract

ObjectiveSerious mental illness is associated with excess cardiovascular risk, but outcomes after contemporary percutaneous coronary intervention (PCI) remain unclear. The purpose of this paper is to examine PCI outcomes among those with serious mental illness.MethodsUsing TriNetX database, adults undergoing PCI with schizophrenia, bipolar disorder, or major depressive disorder were compared with propensity-matched controls without psychiatric diagnoses in this retrospective cohort study. Outcomes included statin and P2Y12 inhibitor prescription, cardiac rehabilitation referral, major adverse cardiovascular events, all-cause mortality, and repeat revascularization at 30 days and 1 year. Hazard ratios are reported as controls relative to psychiatric cohorts.ResultsAfter matching, 6766 patients with bipolar disorder, 52 375 with depression, and 5685 with schizophrenia were analyzed. Use of statins was higher, and antiplatelet therapy was similar in psychiatric cohorts. Compared with controls, bipolar disorder (n = 6766) was associated with higher MACE at 30 days (HR 1.12,

First Page

912174261467881

DOI

10.1177/00912174261467881

ISSN

1541-3527

PubMed ID

42430505

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