The rapid surge of colorectal cancer in children and young adults: a 22-year analysis of the CDC WONDER database.
Document Type
Article
Publication Date
7-2026
Publication Title
Proceedings (Baylor University. Medical Center)
Abstract
BACKGROUND: Early onset colorectal cancer (EO-CRC) is rising globally. We analyzed 22 years of US data to identify specific age, gender, and racial/ethnic groups at highest risk.
METHODS: Using the CDC WONDER database (1999-2020), we analyzed CRC incidence in individuals aged 10 to 44. Trends were quantified via annual percentage change (APC) and average annual percentage change (AAPC) using Joinpoint Regression (v.5.0.2).
RESULTS: The 10- to 14-year age cohort exhibited the most pronounced increase (AAPC 11.25%;
CONCLUSION: The sharp escalation of CRC in pediatric and adolescent populations signals a public health crisis, necessitating increased clinical vigilance and investigation into early life environmental drivers.
Volume
39
Issue
4
First Page
576
Last Page
581
Recommended Citation
Mohamed I, Abuelazm M, Al Zoubi BM, Aref A, Jaber F, Dahiya DS et al The rapid surge of colorectal cancer in children and young adults: a 22-year analysis of the cdc wonder database. Proc (Bayl Univ Med Cent). 2026 Jul;39(4):576-581. doi: 10.1080/08998280.2026.2659523. Epub 2026 May 4. PMID: 42269046
DOI
10.1080/08998280.2026.2659523
ISSN
1525-3252
PubMed ID
42269046