Late-Presenting Myocardial Infarction With PCI and Impella Placement Complicated by Ventricular Septal Defect and Impella Malfunction.

Authors

• Zaheen Hossain, Oakland University William Beaumont School of Medicine Medical Student
• Tai Metzger, Oakland University William Beaumont School of Medicine Medical Student
• Abdullah Jalal, Oakland University William Beaumont School of Medicine Medical Student
• James R. Burmeister, Oakland University William Beaumont School of Medicine
• Ismail Zazay
• Mohamed Abdalaziz, Corewell Health East Resident
• Tucker Billups, Corewell Health East

Document Type

Article

Publication Date

1-14-2026

Publication Title

Journal of investigative medicine high impact case reports

Abstract

Post-myocardial infarction ventricular septal defect (VSD) is a rare but frequently fatal mechanical complication. We report a 67-year-old man who presented approximately 48 hours after symptom onset with dyspnea and was diagnosed with an ST-segment elevation myocardial infarction. He underwent emergent percutaneous coronary intervention supported by Impella placement but subsequently developed a large ventricular septal defect two days later, complicated by Impella malfunction. The patient ultimately underwent successful surgical repair. This case highlights the importance of maintaining a high index of suspicion for mechanical complications in late-presenting myocardial infarction, even after apparent stabilization with revascularization and mechanical circulatory support.

Volume

14

First Page

23247096261454418

Recommended Citation

Hossain Z, Metzger T, Jalal A, Burmeister JR, Zazay I, Abdalaziz M et al [ Billups T] Late-presenting myocardial infarction with pci and impella placement complicated by ventricular septal defect and impella malfunction. J Investig Med High Impact Case Rep. 2026 Jan-Dec;14:23247096261454418. doi: 10.1177/23247096261454418. PMID: 42161315.

DOI

10.1177/23247096261454418

ISSN

2324-7096

PubMed ID

42161315