Concurrent Metastatic Clear Cell Renal Cell Carcinoma and Chronic Lymphocytic Leukemia Within the Same Lymph Node: A Case Report and Review of Dual Malignancy Management.
Document Type
Article
Publication Date
7-7-2025
Publication Title
Cureus
Abstract
Dual malignancies involving clear cell renal cell carcinoma (ccRCC) and chronic lymphocytic leukemia (CLL) present a rare and challenging clinical scenario. This report describes a 75-year-old male with a history of monoclonal B-cell lymphocytosis (MBL) that progressed to CLL, later complicated by the development of ccRCC. Following neoadjuvant pembrolizumab, he underwent left nephrectomy with pathology confirming renal cell carcinoma (RCC). Subsequent imaging revealed a recurrent renal bed nodule, and a retroperitoneal lymph node biopsy demonstrated concurrent CLL and metastatic RCC. Our report aims to enhance recognition and management strategies for such complex dual malignancies.
Volume
17
Issue
7
First Page
e87448
Recommended Citation
Hanona PF, Kiryakoza M, Zhang P, Howard G. Concurrent metastatic clear cell renal cell carcinoma and chronic lymphocytic leukemia within the same lymph node: A case report and review of dual malignancy management. Cureus. 2025 Jul 7;17(7):e87448. doi: 10.7759/cureus.87448. PMID: 40772206
DOI
10.7759/cureus.87448
ISSN
2168-8184
PubMed ID
40772206