Clinical and Metabolic Outcomes of Radiofrequency Ablation with Vertebral Augmentation for Symptomatic Spinal Osteolytic Lesions in Multiple Myeloma.

Document Type

Article

Publication Date

7-2026

Publication Title

Journal of Vascular and Interventional Radiology

Abstract

This retrospective single-center study evaluated clinical and local metabolic outcomes after radiofrequency ablation (RFA) combined with vertebral augmentation in patients with multiple myeloma and symptomatic spinal osteolytic lesions. Twenty patients with 45 lesions underwent treatment between 2018 and 2024 (mean follow-up, 14.6 months). Pain, disability, and functional status were assessed using the visual analog scale (VAS), Oswestry Disability Index (ODI), and Karnofsky Performance Status (KPS). PET-CT at 3-6 months evaluated FDG uptake at treated lesions. Mean VAS improved from 8.2 to 3.8 at 12 months (P < .001), with parallel improvements in ODI and KPS. Mean SUV_max decreased by 62.5% at treated lesions. No new vertebral fractures or progressive collapse were observed, and 2 minor adverse events occurred. RFA combined with vertebral augmentation was associated with sustained pain relief, functional improvement, and reduced FDG uptake, supporting its role as a local palliative and stabilizing therapy.

First Page

108963

Last Page

108963

DOI

10.1016/j.jvir.2026.108963

ISSN

1535-7732

PubMed ID

42468838

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