Trends in Colorectal Cancer Incidence: A comparative Analysis of Michigan and the United States (1999-2021)

Document Type

Conference Proceeding

Publication Date

10-2025

Publication Title

American Journal of Gastroenterology

Abstract

Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths both in the United States and globally. A comprehensive state-specific trend and disparity analysis of CRC incidence can aid in optimizing screening and prevention efforts, and assist researchers in investigating cultural disparities and their underlying causes. This study aims to explore and compare temporal trends in CRC incidence across different demographic strata in Michigan (MI) and the United States. Methods: CRC incidence data from 1999 to 2021 were extracted from the United States Cancer Statistics – Incidence dataset via the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) Online Database. Age-adjusted Rates (AARs) and Crude Rates per 100,000 persons were extracted for a comprehensive analysis. Average Annual Percent Change (AAPC) was calculated via the JoinPoint software. Results: From 1999 to 2021, the overall CRC incidence rates in Michigan closely paralleled national trends, with both showing an AAR of 42.2. Significant declines in CRC incidence were observed in both regions (AAPC: MI; -2.71 CI: (-3.10 to -2.38)), (AAPC: US; -2.30 CI: (-2.52 to -2.05)). Men had greater rates than women with similar incidence across both regions (MI AAR: men 48.2, women 37.2; US AAR: men 48.9, women 36.7). Non-Hispanic (NH) Black/African American individuals had the highest incidence among racial/ethnic groups, Michigan rates were slightly higher (AAR: 52.8) than nationally (AAR: 49.4). Asian/Pacific Islanders had the lowest rates, with Michigan showing relatively lower rates (AAR: 27.4) compared to national rates (AAR: 32.3). Adults aged 851 had the highest incidence rates among all age groups in both Michigan and the US (MI Crude Rate: 309.1, US Crude Rate: 315.4). Notably, CRC incidence in younger/middle-aged adults (age group 40-54 in MI and 25-54 in the US) increased over the last 2 decades, while incidence in adults aged 55+ declined in both regions. Conclusion: CRC incidence trends in Michigan mirrored national patterns over the last 2 decades, with significant declines overall, especially in older adults. Men consistently had higher rates than women, and NH Black/African Americans experienced higher incidence rate among all racial/ethnic groups, with slightly more pronounced Michigan rates. While overall CRC AARs declined significantly, the incidence among younger/middle-aged adults rose (age groups 25-54 in U.S. overall and 40-54 in MI).

Volume

120

Issue

10S2

First Page

S120

Comments

American College of Gastroenterology Annual Meeting, October 24-29, 2025, Phoenix, AZ

Last Page

S120

DOI

10.14309/01.ajg.0001129708.62440.04

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