A Case of Pleomorphic Liposarcoma of the Superficial Distal Upper Extremity

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Authors

Suraj Patel, Corewell Health East Resident
Francisca Kartono, Corewell Health East

Description

• Introduction § Pleomorphic liposarcoma (PLS) is the rarest subtype of liposarcoma, accounting for 5-10% of all liposarcomas1. 
• PLS typically arises in deep soft tissue (e.g. retroperitoneal region, extremities) with aggressive behavior characterized by high rate of local recurrence (42%) and distant metastases (45%)2.
• In contrast, ~25% of PLS develops within the dermis and superficial subcutaneous tissue. Superficial cases exhibit lower rates of recurrence and metastasis3.
• PLS is diagnosed under microscopic examination revealing multi-vacuolated pleomorphic lipoblasts. Without any specific immunohistochemical or molecular features, diagnostic challenges can arise when biopsy reveals scant lipoblasts4.

Publication Date

3-13-2025

Keywords

Pleomorphic liposarcoma

Disciplines

Dermatology

Recommended Citation

Patel S, Kartono F. A case of pleomorphic liposarcoma of the superficial distal upper extremity. Presented at Corewell Health Hospital Farmington Hills 2025 Alvin Yarrows Research Day; 2025 Mar13; Farmington Hills, MI.

Comments

2025 Alvin Yarrows Research Day at Corewell Health Hospital Farmington Hills, Farmington Hills, MI, March 13, 2025.