Characteristics and Trends in Patients with Cardiac Sarcoidosis Presenting with Electrophysiologic Abnormalities: A Single-Center Retrospective Registry Analysis

Authors

• Mohammad Ahmed, Corewell Health West Fellow
• Jack Tietema, Michigan State University College of Human Medicine Medical Student
• Mohamad El Shami, Corewell Health West Resident
• Nabin Manandhar Shrestha, Corewell Health West
• Stephen Orey, Corewell Health West
• Matthew Hollowell, Corewell Health West Fellow
• Wissam Abdallah, Corewell Health West
• Nagib T. Chalfoun, Corewell Health West
• Sanjay Dandamudi, Corewell Health West

Document Type

Conference Proceeding

Publication Date

4-2026

Publication Title

Journal of the American College of Cardiology

Abstract

Background: Cardiac Sarcoidosis (CS) may present with ventricular arrhythmias (VA) and atrioventricular block (AV block). The differences in characteristics and outcomes between these groups are poorly understood.

Methods: Patients discussed at a multidisciplinary (MDT) CS team at a tertiary center were retrospectively analyzed. Baseline characteristics and clinical outcomes including advanced therapies, device implantation, and death were assessed.

Results: 69 patients presented with electrophysiologic abnormalities: 34 with VA and 35 with AV block. Of the patients with VA, 25 presented with sustained VT, 5 with nonsustained VT, and 4 with PVCs. Patients with VA were more likely to have underlying renal (p=0.004) and autoimmune disease (p=0.011), lower mean LVEF (p< 0.001), and a trend towards higher likelihood of heart failure (p=0.058). Patients with AV block had a higher ventricular pacing burden (p=0.001) and a trend towards higher likelihood of device implantation (p=0.05). Patients presenting with VA demonstrated a trend towards increased death (p=0.054).

Conclusion: Patients with CS presenting with VA may have more comorbidities, worse LV function, and higher mortality than those with conduction disease. Patients with AV block have a higher likelihood of device implantation and pacing requirements. Further studies are necessary to better characterize these two groups and understand the mechanisms behind the variability in presentation and associated clinical implications.

Volume

87

Issue

13 Suppl

First Page

A96

Comments

American College of Cardiology 75th Annual Scientific Session & Expo, March 28-30, 2026, New Orleans, LA

Frederik Meijer Heart and Vascular Institute

Last Page

A96

Recommended Citation

Ahmed M, Tietema JM, Shami ME, Shrestha NM, Orey S, et al. [Hollowell M, Abdallah WM, Chalfoun NT, Dandamudi S]. Characteristics and trends in patients with cardiac sarcoidosis presenting with electrophysiologic abnormalities: A single-center retrospective registry analysis. J Am Coll Cardiol. 2026;87(13 Suppl):A96. doi:10.1016/j.jacc.2026.02.238.

DOI

10.1016/j.jacc.2026.02.238

ISSN

0735-1097