Ventricular arrhythmias and mortality in chronic total coronary occlusion: PCI versus optimal medical therapy in patients with LVEF greater than 35.

Document Type

Article

Publication Date

8-11-2026

Publication Title

Future Cardiol

Abstract

BACKGROUND: Ventricular arrhythmia (VA) risk in patients with chronic total coronary occlusion (CTO) without advanced left ventricular (LV) dysfunction is poorly defined, and whether revascularization reduces VA compared with optimal medical therapy (OMT) remains unknown.

METHODS: We conducted a single-center retrospective cohort study of 100 patients with angiographically confirmed CTO, LVEF > 35%, and no coronary artery bypass surgery after diagnosis between January 2010 and January 2019. CTO percutaneous coronary intervention (CTO-PCI) was performed in 44 patients, while 56 received OMT. Primary outcomes were VA and all-cause mortality at study end. Secondary cardiovascular outcomes were assessed. Kaplan - Meier methods were used for VA and mortality analyses, performed with STATA 15 and RStudio.

RESULTS: Mean age was 59.9 ± 13.1 years, BMI was 31.8 ± 7.4 kg/m

CONCLUSIONS: Among CTO patients with LVEF > 35%, VA and mortality were frequent, particularly with OMT, supporting prospective studies to confirm benefit and refine patient selection for revascularization strategies.

First Page

1

Last Page

11

DOI

10.1080/14796678.2026.2712108

ISSN

1744-8298

PubMed ID

42576714

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