Racial and ethnic differences and temporal changes in outcomes following transcatheter aortic valve replacement in urban hospitals.

Document Type

Article

Publication Date

4-30-2026

Publication Title

Cardiovascular revascularization medicine : including molecular interventions

Abstract

INTRODUCTION: Transcatheter aortic valve replacement (TAVR) is an established treatment for severe aortic stenosis. Although TAVR has improved clinical outcomes, data on racial and ethnic differences in in-hospital clinical outcomes and their temporal trends, particularly within urban hospital settings, remain limited. Accordingly, we examined racial and ethnic differences in in-hospital outcomes and their temporal trends among patients undergoing TAVR in urban hospitals.

METHODS: We utilized the National Inpatient Sample from 2016 through 2022 and identified TAVR-related hospitalizations in urban hospitals. Patients were classified by race and ethnicity, with White patients serving as the reference group. Primary endpoints included in-hospital mortality and major adverse cardiovascular events. Secondary endpoints included acute myocardial infarction, stroke, cardiac arrest, acute kidney injury, need for transfusion, mechanical ventilation, and other in-hospital complications. Survey-weighted multivariable analyses were performed.

RESULTS: We identified a weighted total of 469,175 hospitalizations for TAVR in urban hospitals. Overall, 87.1% of patients were White, and 12.9% were racial and ethnic minority patients. Compared with White patients, Black and Hispanic patients had higher adjusted odds of major adverse cardiovascular events, driven in part by acute myocardial infarction, while Hispanic patients also had higher in-hospital mortality. Rates of ischemic and hemorrhagic stroke did not differ significantly across groups. Significant race-by-year interactions were observed for in-hospital mortality and blood transfusion.

CONCLUSIONS: Our findings highlight persistent racial and ethnic disparities in in-hospital outcomes following TAVR, emphasizing the need for targeted efforts to address inequities in care delivery.

Volume

S1553-8389

Issue

30

First Page

00185-5

DOI

10.1016/j.carrev.2026.04.018

ISSN

1878-0938

PubMed ID

42097944

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