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Keywords
Postmastectomy radiation therapy
Disciplines
Anesthesiology | Family Medicine | Oncology | Ophthalmology | Plastic Surgery | Radiology
Description
Postmastectomy radiation therapy (PMRT) utilized as part of a breast cancer treatment regimen reduces the risk of disease recurrence in appropriately selected patients.1,2,3,4,5 However, PMRT increases risk of radiationrelated toxicities that can interfere with breast reconstruction post-mastectomy.6 Following mastectomy, implant-based reconstruction can increase patient satisfaction and quality of life7,8; complications induced by PMRT such as infection and tissue contracture, though, increase risk for implant loss and may ultimately require further surgeries for the patient.
PMRT is delivered based on treatment plans that are optimized to provide appropriate radiation dosages to tissues along the chest wall while simultaneously limiting exposure of surrounding sensitive structures. Subcutaneous lymphatic structures and residual glandular tissue are of major importance as they may harbor microscopic disease that can lead to recurrence.9 The skin and immediate surrounding tissue, therefore, is often exposed to higher doses of radiation to ensure appropriate therapeutic coverage of these structures. How this increased dose delivery may affect a patient’s risk for radiation-related toxicities, however, is currently not well characterized. We hypothesize that near-surface dose to the reconstructed chest wall predicts for an increased risk of significant breast pain as well as the development of acute skin toxicities such as moist desquamation. Identifying dosimetric correlates for these acute toxicities may allow for optimization of radiation treatment planning aimed at reducing the incidence of acute toxicities and further associated complications.
Publication Date
5-2024
Recommended Citation
Thrasher P, Levitin R, Salari K, Squires BS, Hazy AJ, Maywood MJ et al [Delise AP, Almahariq MF, Dekhne N, Oliver L, Chen PY, Walters KJ, Dudley D, Dilworth JT]. Near-surface dose correlates with moist desquamation and unplanned reconstructive surgery in patients with implant-based reconstruction receiving postmastectomy radiation therapy. Poster presented at: Oakland University William Beaumont School of Medicine Embark Capstone Colloquium; 2024 May; Rochester Hills, MI.
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Anesthesiology Commons, Family Medicine Commons, Oncology Commons, Ophthalmology Commons, Plastic Surgery Commons, Radiology Commons
Comments
The Embark Capstone Colloquium at the Oakland University William Beaumont School of Medicine, Rochester Hills, MI, May, 2024.