A perspective for alzheimer disease from gut microbiota-associated NMR-based fecal metabolomics: a study with 5XFAD mice.

Authors

• Nazlıhan Tekin
• Furkan Şahin
• Betül Şahin
• Zelal Zuhal Kaya
• Ali Yılmaz, Corewell Health East
• Stewart F. Graham, Corewell Health East
• Mustafa Serteser
• Ahmet Tarık Baykal

Document Type

Article

Publication Date

4-24-2026

Publication Title

Metabolic brain disease

Abstract

UNLABELLED: Alzheimer’s disease (AD), a neurodegenerative, irreversible, and progressive brain disorder, is characterized by memory loss and cognitive dysfunction. In neurodegeneration, gut microbiota and their metabolites have an impact on behavior and brain function. This study aimed to identify fecal candidate discriminant metabolites in 5XFAD mice assosciated with AD as compared to an age-matched wild-type (WT) healthy mice groups at three different time points (3, 6, and 9 month) using Proton Nuclear Magnetic Resonance (

GRAPHICAL ABSTRACT: [Image: see text]

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11011-026-01848-2.

Volume

41

Issue

1

First Page

91

Recommended Citation

Tekin N, Şahin F, Şahin B, Kaya ZZ, Yılmaz A, Graham SF et al A perspective for Alzheimer disease from gut microbiota-associated NMR-based fecal metabolomics: a study with 5XFAD mice. Metab Brain Dis. 2026 Apr 24;41(1):91. doi: 10.1007/s11011-026-01848-2. PMID: 42029761

DOI

10.1007/s11011-026-01848-2

ISSN

1573-7365

PubMed ID

42029761