Successful Use of Chimeric Antigen Receptor T-cell (CAR-T) Therapy With Lisocabtagene Maraleucel in a Renal Transplant Recipient With Refractory/Relapsed Diffuse Large B-Cell Lymphoma (DLBCL).
Document Type
Article
Publication Date
2-15-2026
Publication Title
Cureus
Abstract
This case describes a 53-year-old male with end-stage renal disease who developed monomorphic post-transplant lymphoproliferative disorder (PTLD) in the form of diffuse large B-cell lymphoma (DLBCL) after kidney transplantation. Despite initial treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP), the patient's disease progressed, and he was referred for chimeric antigen receptor (CAR) T-cell therapy with lisocabtagene maraleucel (liso-cel). Given his post-transplant status, his immunosuppressive agents (tacrolimus and mycophenolate) were held, and prednisone was tapered to 5 mg daily to maintain minimal baseline immunosuppression. After lymphodepleting chemotherapy and liso-cel infusion, the patient experienced no significant toxicities, including cytokine release syndrome (CRS) or immune effector cell-associated neurotoxicity syndrome (ICANS). This case underscores the potential of CAR-T therapy for refractory/relapsed DLBCL in post-transplant patients, emphasizing the need for careful immunosuppressive management to balance graft protection and treatment efficacy.
Volume
18
Issue
2
First Page
e103667
Recommended Citation
Tai W, Chaudhry F, Shahrour N, Thomas J, Anyadibe A, Oyetoran A et al [ Gopishetty S, Idogun P, Samarapungavan D, Sarmad JH, Jaiyesimi I] Successful use of chimeric antigen receptor t-cell (car-t) therapy with lisocabtagene maraleucel in a renal transplant recipient with refractory/relapsed diffuse large b-cell lymphoma (dlbcl). Cureus. 2026 Feb 15;18(2):e103667. doi: 10.7759/cureus.103667. PMID: 41853416
DOI
10.7759/cureus.103667
ISSN
2168-8184
PubMed ID
41853416